Abstract: The technology condition of nuclear grade plutonium dioxide powder clearly defined the necessary items and limits of impurity elements. In order to ensure the quality of the plutonium dioxide powder, an accurate method for determining the trace impurity elements in the nuclear grade plutonium dioxide powder is need to be established. Experiment was developed with HNO₃-HF mixed acid for dissolving plutonium dioxide powder, with 6 mol/L nitric acid solution as eluent, and the strong base anion resin (256×4) is adopted for the separation of plutonium and impurity elements. Instrument parameters are optimized by orthogonal test. Then the trace elements in the plutonium dioxide powder are determined by ICP-AES. For the 50 mg PuO₂ sample, the recovery of the method for most of the elements is between 80%-120% and the s_r is better than 20% ( n =6).The detection limit of the elements is less than 10μg/g Pu.