Abstract: A new flow injection analysis method coupled with potentiometric titration using double indicator electrodes for the precise determination of uranium in uranium mine has been developed. In this method, the titrant is a mixture of ammonium vanadate and sodium fluoride, both platinum electrode and fluoride electrode are inserted in the flow cell. In a process of titration, both the potential of uranium and the volume ratio of the titrant and the titration solution can be obtained simultaneously from the two electrodes at each titration point. The method is free of volumetric and reduces the consumption of reagent and sample. The method is also very quick in analysis rapidity and depresses radiant intensity in the process of analysis. The method has been applied to the determination of the uranium concentrate in uranium mine with the relative standard deviation less than 0.5% (n=3) and the recovery of 99.3%-100.3%.