Abstract: The reaction of uranium and its alloy with oxygen and water vapor has attracted widely attention as an important nuclear material. The oxidation process, reaction rate and products of uranium and its alloy with oxygen, water vapor and humid oxygen has been summarized and discussed. The process of uranium-oxygen systematic reaction includes the adsorption, solution of oxygen on the surface, diffuseness in the crystal lattice which is the determinative step and reaction at the interface of the metal and the oxide. However, the reaction mechanism of uranium-water system was dispersive on the diffuse ion. The uranium-oxygen-water systematic reaction is the result combines the uranium-oxygen and uranium-water reaction.