Abstract: At present, the nuclear power plants including operation units and constructing units at home almost don’t have a unified radioactive solid waste management system, which can manage the radioactive solid wastes from produce to final dispose process. According to the requirements of radioactive waste management from the nuclear power plants, this paper is devoted to develop a general radioactive solid waste management system, which is suitable for various waste management activities, including the waste source term, collecting, treatment, storage, and transportation and final disposal management of the whole process of solid waste. This paper analyzed the regulations and the logic relationship of the whole waste management activities such as the radioactive waste source term, treatment, storage, transport and disposal requirements, system safety design are also analyzed and planed, and developed the radioactive solid waste management system for the nuclear power plants(RSWI). The RSWI is the first whole process radioactive waste management system in China nuclear power plants, which can trace the whole process of the waste management activities, and develop the waste management tracking tickets and database. According to the different solid waste source term (such as filter cartridges and spent resins or concentrates) and treatment process, different radioactivity modelings have been researched, the radionuclide decay calculation model is designed, which can evaluate the solid waste radioactivity level. RSWI has been used in the nuclear power plants of China. This software can be used in CPR1000, EPR and AP1000 nuclear power plants by system configuration. The results of this paper were applied in some NPP at home, and it is proved to improve the level of nuclear power plants of waste management, which has greater security and social significance. The recorded data will help the nuclear power plants realize the radiation protection optimization design and the radioactive waste minimization management.