Abstract: The disposal of spent fuel from the reactors of nuclear power plants and the high level liquid waste(HLW) generated from spent fuel reprocessing is a major concern of developing safe nuclear energy. In order to improve the safety of nuclear energy, to reduce the volume of high level radioactive waste that needs to be monitored for long time in deep geological repository, and to effectively use the limited resources of fissile material, the countries of nuclear energy in the world have developed extraction processes for separating minor actinides ion from the high level liquid waste over the past decades. In recent years, diamides pod-ether compounds have gained more attention in actinide separation. Herein, the recent findings on the complexation of such compounds and actinide ions are summarized from the point view of fundamental chemistry.