Abstract: In this work, the copolymer microgel of N-isopropyl acrylamid-co-acrylic acid (PNIPA-co-AA) were used as a novel adsorbent for removing Ni(Ⅱ) from aqueous solution. The adsorption of Ni(Ⅱ) onto PNIPA-co-AA was studied as a function of contact time, solid/liquid ratio, pH value, ionic strength and temperature. The adsorption isotherm of Ni(Ⅱ) adsorption onto copolymer microgels at different temperature were measured. The results show that Ni(Ⅱ) adsorption onto PNIPA-co-AA is strongly depend on solid/liquid ratio, pH value and ionic strength. Kinetic data indicate that the adsorption process achieves equilibrium within 30 min. Thermodynamics data indicate that the adsorption fits the Langmiur model and its linearized form well and the Ni(Ⅱ) adsorption onto copolymer microgels is a spontaneous and endothermic nature process. The adsorption capacity is not signification reduced after seven times of adsorption-desorption cycles. Ions exchange is the predominant mechanism of Ni(Ⅱ) adsorption onto PNIPA-co-AA. Present study suggests that the copolymer microgels maybe a promising candidate for concentration of heavy metal ions and radionuclides from industrial wastewater.