Abstract: Applying traditional hydrometallurgical process to exploit result in high production costs, low beneficiation and smelting efficiency. This article aims to obtain optimum technological parameters by researching on a granite uranium ore testing laboratory technology, which provide technical basis for in-situ broken & leaching tests for the next step. Uranium ore deposit were sampled processed and full analysised of chemical elements. The tests mainly include mechanical agitation tests, static leaching tests and column leaching tests. The tests suggest a certain granite uranium ore leaches good, consume low amount of acid with high rate and short time of uranium leaching. Compared with the conventional hydrometallurgical process, this research reforms the conventional liquid lay out mode of sulfuric acid concentration process. Low-high-low periodical liquid layout mode is adopted instead of conventional high-low mode. The precipitation of calcium sulfate was effectively prevented. Moreover the costs are reduced.