Abstract: Vapor phase catalytic exchange (VPCE) is one of the important methods for water detritiation. This paper focuses on investigating the catalytic performance of the nickel which could replace platinum catalyst for HDO-H₂ static and dynamic experiment under different conditions. The experimental results show that when the temperature is over 200℃, and the pressure as well as the mole ratio of HDO-H₂ are higher, the nickel catalyst exhibits better catalytic effect in static experiment. It is also found that Ni with high loading has a better catalytic performance than Pt. In the dynamic experiments, the resultant deuterium concentration is about 1% which is in agreement with the results of static experiments. The resultant deuterium concentration is higher when there is more HDO. This study shows that cheap metal Ni catalyst can effectively replace noble metal Pt in HDO-H₂ exchange reaction, which is of importance in the practical application.