Abstract: High-level radioactive waste would transport into groundwater by a large number of “channels” in the granite fracture. The study of the migration law can provide theoretical data for control of high-level waste. The following experiments were designed and carried out: Na, Cu and U transport experiment in granite rock. The experimental results show that: (1) With increasing distance, the concentration of peak value is decreasing and tailing phenomena is more obvious; (2) The maximum degree of tailing phenomena is curve of Cu and minimum degree of tailing phenomena is curve of U; (3) Longitudinal disperse coefficient for Na, Cu and U in granite rock range from 0.084 2 m to 0.107 7 m, from 0.092 1 m to 0.116 2 m and from 0.095 8 m to 0.133 7 m respectively. Meanwhile, transverse dispersion coefficient for Na, Cu and U respectively is 0.000 77 m,0.000 66 m,0.000 30 m.