Abstract: Liquid phase catalytic exchange(LPCE) is a very efficientive method to remove small quantities of tritium from light or heavy wastewater streams, and the hydrophobic catalysts copolymer SDB acts as a carrier for active component-Pt, playing a key role in LPCE. In this paper 30 mm×400 mm glass column has been used to simulate bed catalytic reactor, and the effect of packing mode and volume ratio of SDB carrier to stainless steel θ packing on the pressure drop of column were investigated. Similarly, the effect of gas flow rate, liquid flow rate, as well as temperature on the pressure drop of column and liquid holdup were studied. The results indicate that when the packing volume ratio is 4∶1, the pressure drop of column increases with the gas and liquid flow rate, as well as the temperature, and the liquid holdup decreases with the increase of the gas flow rate, while increased with the liquid flow rate, have nothing to do with the loading mode. The pressure drop of layered packing is higher than mixed packing. For the pressure drop of different layered packing, the sort from largest to smallest is quadruple-layer>triple-layer>single-layer>double-layer.