Abstract: The fluorescence analysis method is one of the most important methods for uranyl ion detection with the advantages of simple equipment, high sensitivity and high selectivity. In this paper, the important research results of organic fluorescent molecules for uranyl ion detection in recent years are reviewed, mainly including sensing application of natural fluorescences such as organic fluorescent dyes and drug molecules, and novel organic fluorescent developed with schiff base, porphyrin, amidoxime and AIE molecule. This will provide a facile approach for rational design of new materials with better performance and application of uranyl ion detection.