Abstract: Uranium is an important naturally radioactive element and a typical nuclear fuel. In the process of uranium mining, nuclear power generation, and spent fuel reprocessing, a large amount of uranium-containing wastewater may be released into the environment, causing a huge potential threat to the ecological environment and human health. Reduction of soluble U(Ⅵ) to insoluble U(Ⅳ) oxide has been considered to be an important approach to eliminate radioactive pollution associated with uranium. This review summarizes the common reduction methods, such as zero valent iron reduction, microbial reduction, and photocatalytic reduction for the treatment of uranium-containing wastewater. The advantages and drawbacks of these methods are compared and the related future perspectives are also given.