Abstract: The release of key elements and corrosion behavior of simulated HLW glass were investigated in multimedia environment. Beishan monzonitic granite, Gaomiaozi bentonite and simulated Beishan underground water were added to the micro-reactor at a certain mass ratio, while the glass piece was placed in bentonite at 90 ℃. The reaction lasted from 7 days to 720 days. The leaching concentration of the elements in solution was analyzed using ICP-MS/AES. Scanning electron microscopy and energy dispersive spectrometer were utilized to determine the cross-section morphology of the glass and the elemental distribution of the corrosion interface. The results show that the leaching concentrations of the elements approach saturation after 180 days’ experiment. The initial corrosion of glass is not obvious, while there exists a clear corrosion layer after 90 days. After 360 days’ experiment, heterogeneous corrosion occurrs on the glass surface and wedge-shaped corrosion area forms on the corrosion interface. The average corrosion rate of the glass is 0.4 μm/d in multimedia environment.