Abstract: A new BiCuSO-based material was synthesized, and the effects of pH, time, initial U(Ⅵ) concentration, and temperature on the adsorption of uranium were investigated through batch experiments. The results show that the best adsorption effect is achieved at pH=6.5 and t=120 min, then the maximum adsorption capacity is 572.6 mg/g（ρ₀(U(Ⅵ))=1 000 mg/L）. Kinetic and thermodynamic simulations show that the adsorption conforms to the pseudo-second-order kinetics and Freundlich isotherm adsorption model. Meanwhile, ΔG<0 indicates that the reaction is spontaneous at different temperatures. Additionally, X-ray diffraction(XRD), infrared spectroscopy(FTIR), scanning electron microscopy(SEM) and other characterization methods were used to characterize the samples before and after adsorption to explore the mechanism of adsorption, which can support theories to deal with uranium for advanced materials.