Abstract: Radiopharmaceuticals are one of the important cornerstones of nuclear science and technology in medical application. The research on clinical transformation and application of radiopharmaceuticals in China lags behind that in foreign countries, and there are some problems in our country. It is imperative to develop new radiopharmaceuticals with independent intellectual property rights and clinical application prospects. This paper reviews the current situation of the application of radiopharmaceuticals in China, analyzes the potential common problems in the development of radiopharmaceuticals in China through horizontal comparison and vertical analysis, and in combination with the current clinical transformation of small molecular peptide radiopharmaceuticals application research, which has been continuously promoted in varying degrees, this paper analyzes the existing problems in depth, and puts forward the research and development of new radiopharmaceuticals with application prospects and clinical transformation importance and necessity.