Abstract: Ionic liquids are novel green chemical solvents with broad application prospects in many fields. At present, ionic liquids have been applied in the field of radionuclide labelling. In the article, the applications of ionic liquids in labeling of several important radionuclides or their stable isotopes are introduced. In ¹⁸F and¹²⁵I labelling, the use of ionic liquids can promote the progress of the reaction, simplify the process of labelling, shorten the time, and reduce the amounts of by-products. In addition, the ionic liquids are also applied in the labelling of ⁹⁹Tc^m, and ⁶⁸Ga because of the high solubility of ionic liquids for metal ions and good buffering capacity. As a new application direction, the application of ionic liquids in radionuclide labelling may prompt the development of radiopharmaceuticals.