Abstract: The serious corrosion of copper alloy and its pipes in the marine environment is the key factor that leads to the failure of heat exchangers and piping systems of major equipment such as ships and coastal power stations, and causes huge economic losses and safety accidents. Therefore, this paper proposes an environmentally friendly surface treatment method for copper, wherein a fluorosilane self-assembly film is fabricated on the copper surface. The effects of self-assembly time, solution temperature, and concentration of fluorosilane on the corrosion resistance of the film are investigated. The corrosion performance, hydrophobicity, surface composition, morphology, and structure of the self-assembled film are characterized by electrochemical testing, water contact angle measurement, scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy(EDX), and infrared spectroscopy. The results of SEM and EDX confirm that fluorosilane self-assembles on the Cu surface, while infrared spectroscopy identifies characteristic functional groups(C—F and Si—O) in the self-assembled film, explaining the corrosion resistance and hydrophobic mechanisms. Electrochemical tests show that, under conditions of a self-assembly time of 2 hours, a solution temperature of 30 ℃, and a fluorosilane concentration of 20 mmol/L, the self-assembled film exhibits strong corrosion resistance with a corrosion current density of 2.9 × 10⁻⁹ A/cm², a corrosion inhibition efficiency of 99.9%, and a water contact angle of up to 138.0°. This study provides a reference for the corrosion protection of copper and its alloys used in marine nuclear power facilities.