Abstract: 　　⁶⁸Ga is one of the most widely used PET diagnostic radionuclides in clinical practice, primarily sourced from ⁶⁸Ge‑⁶⁸Ga generators. This study focuses on developing a filler material suitable for ⁶⁸Ge‑⁶⁸Ga generators. It compared the performance differences of TiO₂ adsorbents prepared via three processes: the sol‑gel method, the hydrothermal method, and the alcohol-based solvothermal method. Based on the characterization of the structure, morphology, specific surface area, and chemical stability of the prepared TiO₂ materials, an anatasephase TiO₂ adsorbent with excellent overall performance was selected, and its optimized preparation process was established. The results show that TiO₂ prepared by the sol-gel method possesses superior physicochemical properties, reflected in higher ⁶⁸Ga elution efficiency and lower ⁶⁸Ge breakthrough, making it more suitable as an adsorbent filler for generators. Under optimized process conditions, the anatasephase TiO₂ material was used in a microcurielevel ⁶⁸Ge⁶⁸Ga generator experiment. Using 0.1 mol/L HCl for elution, the ⁶⁸Ga elution efficiency remained between 60% and 80% over 270 days, while the ⁶⁸Ge breakthrough rate was below 10^-3%, demonstrating high selectivity for adsorbing ⁶⁸Ge. This meets the nuclide separation standards and longterm usage requirements for both commercial and laboratorygrade ⁶⁸Ge⁶⁸Ga generators. This study provides an important reference for the development of key adsorbent materials for ⁶⁸Ge⁶⁸Ga generators.