Abstract: The solution reactor has advantages in medico-isotope production. The history of the development of homogeneous solution-type reactor, its technical properties and related fuel reprocessing process have been introduced, mainly for isotopes ⁹⁹Mo, ¹³¹I, ⁸⁹Sr. 30% TBP solvent extraction reprocess is recommended to treat spent-fuel of homogeneous reactor. The recovery ratio for uranium is more than 99.5% while radio concentration>99% of fission and corrosion products are removed in the reprocess. Solution of spentfuel can be reprocessed after 1-2 years of operation and cooling for 3-5 months. Small type equipments, such as centrifugal extractors are preferred for the process.