Abstract: STUDY OF TECHNETIUM CHEMISTRY Ⅹ.QSAR ANALYSIS OF 99TcmLABELLED N2S2 ANALOGUES OF BRAIN IMAGING AGENTSMeng Zhaoxing Jia Hongmei Yang Wen Liu Boli(Department of Chemistry,Beijing Normal University,Beijing 100875)ABSTRACTQuantitative structure activity relationship (QSAR) analysis of the correlations between initial brain uptake and structure parameters,for example lipophilicity Fr,molar refractivity MR and electronic parameters σI of the 99TcmN2S2 complexes have been studied with multiple regression analysis method.The main structural factors which affect the initial brain uptake of this kind of brain imaging agents have been discussed.The results may give some theoretical informations for designing new brain imaging agents.Key words QSAR Brain uptake 99TcmN2S2 Analogues of brain imaging agents Multiple regression analysis