三羰基铼~(188)Re的放射化学合成

Radiosynthesis of Tricarbonal Rhenium~(188)Re

摘要: 合成了化合物N(Et)42Re(CO)3Br3,并用IR,ICPMS,元素分析等方法对化合物进行了表征。分析了此化合物溶于水后,阴离子部分的3个Br-可定量地被3个H2O分子取代,得到前体化合物facRe(CO)3(H2O)3+。同时合成了放射性前体化合物fac188Re(CO)3(H2O)3+,放化产率约为80%,SepPak分离后,放化纯度大于95%。通过HPLC分析比较了这两个前体,确定了放化前体fac188Re(CO)3(HO)+的结构。

Abstract: The complex of N(Et)42Re(CO)3Br3 is prepared and characterized by IR, ICP-MS, elemental analysis. When the complex is dissolved in water, the three Br- ligands are quantitatively exchanged by three water molecules and the precursor of fac-Re(H_2O)_3(CO)_3+ can be obtained. The complex of fac-188 Re(H_2O)_(CO)_3+ is synthesized with an overall radiochemical yield of 80%, and with more than 95% radiochemical purity after Sep-Pak separation. The complex of fac-Re(H_2O)_3(CO)_3+ taken as a standard sample, the structure of the precursor, fac- 188 Re(H_2O)_3(CO)_3+, is confirmed by HPLC.