冠醚法标记肾上腺显影剂NCL-6-I的动力学研究

STUDY OF KINETICS IN LABELLING THE ADRENAL IMAGING AGENT NCL-6-I BY THE CROWN ETHER METHOD

摘要: <正> 一、前言 6β-碘甲基-19-去甲胆固醇(简写NCL-6-I)的放射性碘标记物是目前临床常用的肾上腺显影剂。标记方法有丙酮法、丙酮-乙腈法、乙醇法及乙腈法,近来又采用熔融法和冠醚法等。熔融法和冠醚法都具有反应快速和产额高等特点。但迄今为止,关于冠醚法标记过程的反应动力学缺乏系统的研究。冠醚法标记方法分两类:(1)冠醚催化交换(简写为CEC),冠醚以催化量加入反应溶剂;(2)冠醚介质交换(简写为CEM)。标记物一般只有1-5mg,冠醚一般在20mg以上,冠醚既作为相转移催化剂,又

Abstract: Radioiodination of NCL-6-I is achieved by means of the crown ether method. Kinetics in the 18-C-6 crown ether medium is investigated. The results indicate that the isotopic exchange reaction between NCL-6-I and Na 125I is a second order reaction. The rate constant of reaction is determined by a straight line between -In (1-F) and t. Our results show that the crown ether labelling method is characterized by high yield, rapidity and conveniece.