Abstract: 242Cm is a highly a radioactive nuclide (3.3 Ci/mg),which has many uses in technique and scientific research, and its preparation in 100 Ci quantity has been reported before in China. A new method of its preparation in curie quantity is here reported consisting of two stepes of chromatography, a TBP extraction and an anion exchange resin.This method is more simple and gives a purer product than the method used before and an advanced γ monitor on line is used.