Abstract: HEDTMPN-(2-hydroxyethyl)ethylenediamine-1,1,2-tri(methylenephosphonic acid is synthesized and labeled with 117Sn m(Ⅳ).The labeling conditions,stability,lipophiljcity and biodistribution of 117Sn m-HEDTMP in mice are investigated. The results show that the labeling yield of HEDTMP with 117Sn m(Ⅳ) is higher than 95% in 5 min after reaction at room temperature. Acidity and ligand dosage exert great influence to exterior of reaction solution, but labeling yield is still high. The 117Sn m-HEDTMP is very stable at room temperature and 37 ℃ and is hydrophilic. The biodistribution experiments of 117Sn m-HEDTMP in mice show that uptake of the membra bone is higher at 4 h after injection, the uptake of other tissues is low.