~(125)I标记多巴胺D_3受体显像剂的合成

SYNTHESIS OF ~(125)I LABELED DOPAMINE D_3 RECEPTOR IMAGINING AGENT

摘要: 制备了12 5I标记的具有多巴胺D3 受体潜在活性的核药物12 5I 7 OH PIPAT(7 羟基 2 (N 丙基 N 3’ 碘 2’ 烯丙基 )氨基四氢萘满 )。从化合物 2 ,7 二羟基萘开始 ,经过多步反应合成出12 5I 7 OH PIPAT的前体 ,并对它进行12 5I标记。12 5I 7 OH PIPAT经分离纯化后 ,检测结果为 :放射化学产额为 5 7% ,放化纯度大于86 %。

Abstract: 125I labeled radiopharmaceutical 125 I PIPAT having selective and affinitive to dopamine D 3 receptor is synthesized. Preparation of 125 I 7 OH PIPAT is from multi step reactions. The radiochemical yield is 57%.The radiochemical purity is higher than 86%.