Abstract: PRODUCTION OF ~(201)TICI INJECTION WITH DIETHYLAMMONIUM DIETHYLDITHIOCARBAMATE- BUTYLACETATATE EXTRACTION METHODFANG YIBING；FU YONGHANG；MIAO LIN ZHAO YONGJUN；PAN QIYUAN；LI BO LIU PEIHUA；WANG HAN；FENG JINGLING GUO XINMING；ZHANG SU；CHEN HONGTAO（Institute of High Energy Physics，Academia Sinica，Beijing，100039）ABSTRACT The extraction of Pb and Tl（Ⅰ）with butylacetate solution of diethylammonium di-ethyldithiocarbamate（DDDC）is studied.The DDDC-butylacetate extraction method for~(201)TlCI injection production from natural Tl target irradiated by 29－22 MeV proton beam isdeveloped．~(201) pb is separated from 0．3－0．4mol／l HNO_3 solution of Tl target with 0．2％DDDC-butylacetate and stripped into 4. 5mol／l HCl． The accumulated ~(201)Tl is then oxidatedto Tl（Ⅲ）with KBrO_3 and separated from Pb－activity with butylacetate extraction and final-ly ，is stripped back into diluted H2SO_3． The results of 18 production runs of total amount3．18 × 10~(10)Bq show that the quality of all injections meets the requirements of the UnitedStates Pharmacopeia. The chemical yield is 84％±2％， while the chemical separation time is2．5－3h． The method can also be used for production of ~(203)pb with the chemical yield of 84％±3％and nuclear purity of＞99．9％。The results of safety test， biodistribution in mice andrabbit imaging of the injections are good. The clinical experiments of 124 cases are per-formed. The quality of myocardial images and the efficiency of diagnoses are satisfactory. Key words ~(201)TlCI injection ~(203)pb DDDC Butylacetate Solvent extrac- tion