心肌显像剂~(68)Ga(BAT-TECH)的一些基本常数测定

摘要: 研究了心肌显像剂￣（６８）Ｇａ（ＢＡＴ－ＴＥＣＨ）的动力学性质，测定了它的热力学常数。实验结果表明，ＢＡＴ－ＴＥＣＨ与柠檬酸镓的配体交换反应为二级反应，反应速率常数ｋ为０．５０ｌ／ｍｏｌ·ｓ，反应活化能Ｅ＿ａ＝５６．６ｋＪ／ｍｏｌ；￣（６８）Ｇａ（ＢＡＴ－ＴＥＣＨ）的稳定常数ｌｇβ＝１４．９，配体ＢＡＴ－ＴＥＣＨ的四级氢解离常数ｐＫ＿１＝４．６２，ｐＫ＿２＝７．６８，ｐＫ＿３＝８．６８，ｐＫ＿４＝１１．２。

Abstract: MEASUREMENTS OF SOME BASIC CONSTANTS OF~(68)Ga（kAT-TECH）AS AN IMAGING AGENTCHEN HUAWEI; LIU BOLI（Department of Chemistry ，Beijing Normal University，100875）ABSTRACT The kinetic properties of a new myocardial imaging agent ~(68)Ga（BAT-TECH）are investiga-ted and its thermodynamic constants are measured．The results are as follows：Citrate→BAT-TECH exchange reaction order is second-order；reaction rate k＝0．50l／mol·s；activation energyE_a＝56. 6kJ／mol；the stability constant of ~(68)Ga（BAT-TECH）lgβ＝14．9；the acid dissociationconstants of BAT-TECH pK_1＝4．62 ，pK_2＝7．68，pK_3＝8．68，pK_4＝11．2.Key words yocardial imaging agent ~(68)Ga（BAT-TECH）Method of nonlinear least square fitting