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骨肿瘤治疗药物的研究 Ⅰ.~(153)Sm及~(153)Sm-EDTMP的制备

骨肿瘤治疗药物的研究 Ⅰ.~(153)Sm及~(153)Sm-EDTMP的制备[J]. 核化学与放射化学, 1991, 13(4): 233-233.
引用本文: 骨肿瘤治疗药物的研究 Ⅰ.~(153)Sm及~(153)Sm-EDTMP的制备[J]. 核化学与放射化学, 1991, 13(4): 233-233.
STUDIES ON BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS Ⅰ. PREPARATION OF ~(163)Sm AND ~(153)Sm-EDTMP LUO SHUNZHONG PU MANFEI LI YUQIAN LIU ZHONGLIN[J]. Journal of Nuclear and Radiochemistry, 1991, 13(4): 233-233.
Citation: STUDIES ON BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS Ⅰ. PREPARATION OF ~(163)Sm AND ~(153)Sm-EDTMP LUO SHUNZHONG PU MANFEI LI YUQIAN LIU ZHONGLIN[J]. Journal of Nuclear and Radiochemistry, 1991, 13(4): 233-233.

骨肿瘤治疗药物的研究 Ⅰ.~(153)Sm及~(153)Sm-EDTMP的制备

STUDIES ON BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS Ⅰ. PREPARATION OF ~(163)Sm AND ~(153)Sm-EDTMP LUO SHUNZHONG PU MANFEI LI YUQIAN LIU ZHONGLIN

  • 摘要: 作者用天然丰度的钐氧化物(Sm_2O_3,~(152)Sm丰度为26.7%)作靶料,在中子注量率为4×10~(13)n/cm~2·s的条件下,照射时间大于110h,可得核纯很高。比度不低于5.18GBq(140mCi)/mg Sm_2O_3的~(153)Sm。~(153)Sm与EDTMP(乙二胺四甲撑膦酸)络合条件的研究表明:在pH为8-10的范围内,沸水浴中反应30min,~(153)Sm-EDTMP产率大于98%。采用~(153)Sm示踪法测定了Sm(~(153)Sm)-EDTMP的组成,结果证明,Sm(~(153)Sm)与EDTMP络合组成为1:1。~(153)Sm-EDTMP稳定性实验结果表明:在络合物形成后的一个星期内,产率基本不变。
    Abstract: In this paper, 153Sm with high radionuclear purity and specific activity (5.18GBq (l40mCi) /mg Sm2O3) is prepared by irradiating natural Sm2O3 (152Sm,26.7%) sample, replacing costly enriched Sm2O3 target, at a flux of 4×1013n·cm-2·s-1 for a period up to 110h. The yield of 153Sm complexes with EDTMP is up to 99% at pH 8-10, in boiling water bath for 30min. The formation of Sm(153Sm)-EDTMP is measured by 153Sm tracer technique. The results show that the ratio of Sm(153Sm)to EDTMP is 1:1.
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出版历程
  • 收稿日期:  1990-09-23
  • 刊出日期:  1991-11-19

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