Abstract: In this paper the preparation of Pt-C-PTFE hydrophobic catalyst is described. The experiments of T-H isotope exchange between H2/H2O by Pt-C-PTFE hydrophobic catalyst were carried out at 30℃,50c℃ and 75℃ respectively. Within the limits (9.65-38.22) cm/s catalystic activity increases with increase of hydrogen flow rate. Catalystic activity at 50℃ is optimum. Catalystic activity of this catalyst between gas-liquid is larger than that between gas-vapour. Mixture of the hydrophobic catalyst with hydrophilic filler in the bed can improve hydrogen isotope exchange.