Abstract: By studying the ion exchange properties of 11 inorganic exchangers towards Pb2+, Tl3+ and Tl+, CeSiP is prefered for the separation of 201T1 from 201Pb. Its ion exchange properties, the capacity and the washing characters of the ion exchange column are studied. A 201Pb-201Tl generator is prepared. A yield of 83.5% and a radionuclide purity of greater than 99.0% for 201T1 is achieved for the generator.