Abstract: The radiopharmaceutical chemistry is an important part in applied radio-chemistry. In this paper is given a review of in vivo radiopharmaceuticals in our country in recent years. It should be pointed out that in vivo radiopharmaceuticals including diagnostic and therapeutic have enjoyed rapid development. Recently, a series of reactor and cyclotron produced medical radionuclides and their radiopharmaceuticals, especially new 99mTc labelled brain perfusion imaging agents 99mTc-dl-HMPAO, 99mTc-ECD, myocardial perfusion imaging agents 99mTc-CPI and MIBI, radioimmunoimaging agents etc. have heen reported. Furthermore, R and D suggestions and future trends are discussed.