初探纸层法分析放射性药物的R_f值——汞离子的析层行为

PRELIMINARY STUDY ON THE Rf VALUES FOR RADIOACTIVE PHARMACEUTICALS BY PC——CHROMATOGRAPHIC BEHAVIOUR FOR THE MERCURY ION

摘要: <正> 一、引言放射性药物的放化纯度是该产品的质量控制指标之一,其鉴定分析方法,多采用纸层法和高效液相色谱法。无论那一种方法都得预先使用对照品(标准品)进行条件试验,以确定放射性组分的峰位,它们各以比移值R_f和保留时间t_R来表示。美国药典对放化纯度项目的鉴定大多数采用在相同实验条件下与对照品对比以确定峰位,而我国药典尚未给予注意。作者试图对纸层法的R_f值进行初步的探讨。

Abstract: This paper describes the Rf values under different experimental conditions by paper chromatography, which has been applied to determine the radiochemi-cal purity of radioactive Pharmaceuticals. It is found that the Rf values depend strongly on sample concentration and the kind of developer used.