Abstract: A single column combined with indirect UV detection on the HPLC instrumentation has been found to give a separation system of high efficiency and a good selectivity for inorganic anion NO2-, NO3- and SO42-. This method needs no suppression column and special ion chromatography instrument, and permits fast separation with convenience and sensitivity as well as reliability.lt can be also used to detect other anions such as F-, Cl-, Br- and HPO42-.Separation was carried out in the phase system consisting of Vydac 302 IC support as the stationary phase and. 7 mmol/1 potassium hydrogen phthalate/4 mmol/1 phthalic acid(80/20, V/V, pH=3.9)as the mobile phase. Anion of the off-gas effluent from high-level radioactive waste vitrification can be analyzed in 12 minutes using a UV monitor at 300 nm with a precision of 0.2-1.0% at the 10-7-10-8g level.