Abstract: METABOLISM OF 64Cu AND TRANSFER OF 125IMT IN THE BEARING LIVER ASCITES TUMOR (H22) MICEHuai Qing Fang Xingwang Wang Wenqing(Technical Physics Department of Peking University,Beijing 100871)Huang Guojian Zhou Shu(The ChinaJapan Friendship Hospital,Beijing 100029)ABSTRACTThe metabolism of 64Cu in some tissues of the bearing liver ascites tumor mice has been studied.The liver in normal and tumor bearing mice preferentially accumulates intravenous injection copper,however,the liver in the later mice accumulates much less copper than that of the former.It suggests that in the bearing ascites tumor mice,ascites tumor influences the metabolism of copper.It is found that the content of 64Cu in the tumor cell is more than 85% in ascites tumor.Gel filtration profile of mice liver homogenate on Sephadex G75 shows that injected 64Cu is mainly bound with metallothionein.The tissues uptake of 125Ilabelled (Cd,Zn)MT which is given in abdominal cavity are also reported.Of the tissues studied,the ascites tumor and kidney accumulate the highest concentration of given 125IMT,since over 20% of entire dose accumulated in them.After 125IMT is given,it soon goes into ascites tumor,and reaches the maximum in ascites as well as in tumor cell.Therefore,125IMT can go through the membrane of tumor cell and reaches in the tumor cell.Key words Metabolism of copper Metallothionein 125IMT