Abstract: STUDY OF TECHNETIUM CHEMISTRY ⅪSTUDY ON QSAR OF ISOMERS OF 99Tcm BRAIN RADIOPHARMACEUTICALSJia Hongmei Meng Zhaoxing Liu boli(Department of chemistry,Beijing Normal University,Beijing 100875)ABSTRACTThe relationship between the stereo structure of a compound and its brain uptake for twenty isomers of 99TcmN2S2 brain imaging agents has been studied with multiple regression analysis.The relevant QSAR equations have been found.Furthermore,the reason why the antiand synisomers possess different property in brain uptake has been discussed.Key words Isomer Structureactivity relationship Brain uptake 99Tcmbrain radiopharmaceuticals