~(99)Tc~m-HMPAO构效差异的研究──GSH水溶液中~(99)Tc~m-HMPAO水解动力学分析

摘要: 从化学动力学角度对ｄｌ－型和ｍｅｓｏ－型￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ构效差异的原因进行了研究。通过测定￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ两种异构体在ＧＳＨ和Ｌ－半胱氨酸水溶液中的解离反应的一级速率常数，比较了Ｌ－半胱氨酸和ＧＳＨ对￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ作用，解释了ｄｌ－型和ｍｅｓｏ－型￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ药效的差异，探讨了￣（９９）Ｔｃ￣ｍ－ｄｌ－ＨＭＰＡＯ在人脑中的贮留机理。

Abstract: STUDY ON STRUCTURE-ACTIVITY RELATIONSHIP OF~(99)Tc~m-HMPAO──THE KINETIC ANALYSIS OF ~(99)TC~m-HMPAO DECOMPOSITION IN GSH SOLUTIONYUAN HUI; HUANG JINJIE; DANG SHUQIN（China Institute of Atomic Energy，P.O. Box 275（88 ），Beijing 102413）ABSTRACT The structure－activity relationship of dl-and meso-~99Tc~m-HMPAO is chemdynamicallystudied．The first order rate constant of~(99)Tc~m-HMPAO decomposition in GSH solution ismeasured，and used to explain the different imaging effects of dl- and meso-~(99)Tc~m-HMPAO. Theretained mechanism of ~(99)Tc~m-dl-HMPAO in human＇s brain is discussed.Key words~(99)Tc~m-HMPAO Dlastereoisomer L-Glutathins（GSH ） First order rate Constant.