Abstract:
THEPREPARATIONANDBIODISTRIBUTIONOFNEWBRAINANDMYOCARDIUMIMAGINGAGENT99TcmN┐MDTCLiuGuozhengLiuBoli(DepartmentofChemistry,BeijingNormalUniversity,Beijing100875)ABSTRACTTheoptimumconditionsoflabelingS-methyldithiocarbazatewith99Tcmareobtainedandthebiodistributionof99TcmN-MDTCinmice(18—22g)isevaluated.Theresultsofthebiodistributionshowsignificantaccumulationandperfectretainingof99TcmN-MDTCinmousemyocardiumandbrain.Thebrainandmyocardialuptakesare0.38%、0.82%at2minand0.41%、0.70%at15minrespectively.KeywordsRadiopharmaceuticalsLabelingS-methyldithiocarbazateTcNcoreBiodistribution