心、脑显像剂~(99)Tc~mN-MDTC的制备及生物分布

    • 摘要: 制备了一种99Tcm心、脑显像剂——二硫代肼甲酸甲酯锝氮配合物(99TcmN-MDTC),并研究了该标记化合物在小鼠体内的生物分布。结果表明,此配合物在心、脑中均有一定浓集,并有很好的滞留性质。

       

      Abstract: THEPREPARATIONANDBIODISTRIBUTIONOFNEWBRAINANDMYOCARDIUMIMAGINGAGENT99TcmN┐MDTCLiuGuozhengLiuBoli(DepartmentofChemistry,BeijingNormalUniversity,Beijing100875)ABSTRACTTheoptimumconditionsoflabelingS-methyldithiocarbazatewith99Tcmareobtainedandthebiodistributionof99TcmN-MDTCinmice(18—22g)isevaluated.Theresultsofthebiodistributionshowsignificantaccumulationandperfectretainingof99TcmN-MDTCinmousemyocardiumandbrain.Thebrainandmyocardialuptakesare0.38%、0.82%at2minand0.41%、0.70%at15minrespectively.KeywordsRadiopharmaceuticalsLabelingS-methyldithiocarbazateTcNcoreBiodistribution

       

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