HPLC对~(99)Tc~m发生器洗脱液中高锝酸盐的分析和测定

HPLC对~(99)Tc~m发生器洗脱液中高锝酸盐的分析和测定

摘要

摘要: 利用反相ＨＰＬＣ对凝胶型￣（９９）Ｍｏ－￣（９９）Ｔｃ￣ｍ发生器洗脱液中高锝酸盐（ＴｃＯ）进行了分析鉴定和含量测定，并与液闪法测量结果进行了比较。在实验条件下，ＴｃＯ的ＨＰＬＣ色谱峰的保留时间（Ｒ＿ｔ）为（３．００±０．０５）ｍｉｎ，其峰高与浓度呈线性关系（相关系数为０．９９９）。方法对ＴｃＯ的检测限为１。５×１０￣（－８）ｍｏｌ／ｌ，化学回收率为９５％－１０５％，方法还可用于￣（９９）Ｔｃ￣ｍ标记放射性药物（药盒）中高锝酸盐的检测。

Abstract: THE IDENTIFICATION AND QUANTITATION FOR PERTECHNETATE IN THE ELUENT OF ~(99)TC~m GENERATOR BY HPLCLIU NING；ZHANG SHUYUAN；JIN JIANNAN；CHENG HENGLIU；ZHOU MAOLUN（Institute of Nuclear Science and Technology，Sichuan University，Chengdu 610064）ZHANG LIZHU；LI MAOLIAN（Nuclear Power Institute of China，Chengdu 610005）ABSTRACT The reversed phase HPLC is used to identify and quantify the pertechnetate in the eluent of~(99) Tc~m generator.The retention time of TcO is（3．00± 0．05）min and the detection limit forTcO is 1．5×10~(-8)mol／l．The Chromatorgraphic peak hights and concentration of TcO have agood linear relation with a relation coefficient of 0．9991．The HPLC procedure is also suitable forthe detection of pertechnetate in the radiopharmaceutical kits labeling with ~(99)Tc~m.Key words ~(99)Tc~m -generator Pertechnetate HPLC

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