~(188)Re-NEMMPTDD的制备及生物分布研究

Synthesis and Biodistribution of ~(188)Re-NEMMPTDD

摘要: 在合成新配体NEMMPTDD(2,2,9,9 四甲基 4,7 二氮 4 乙撑 (3,5 二甲基)哌啶 1,10 二硫癸烷)的基础上,以SnCl2 作还原剂制备了188Re NEMMPTDD。生物分布研究表明,该配合物的碘化油溶液具有较理想的肝摄取和滞留,非靶组织的摄取和滞留相对较低,配合物主要通过肾和胃肠代谢。

Abstract: On the basis of synthesizing new ligand of NEMMPTDD (2,2,9,9-tetramethyl-4,7-diaza-4-piperidinyl-ethyl-1,10-decanedithiol),~(188)Re-NEMMPTDD is prepared with the reducing agent of SnCl_2. The biodistribution results show that the lipiodol solution of ~(188)Re-NEMMPTDD exhibits certain uptake and retention in liver and lower uptake and retention in other tissues and is metabolized by kidney, the intestines and stomach.