Abstract: Several factors which effect the determination of 241Am by extraction-liquid scintillation counting are discussed.The interference of other α-particlcs and low energy β-particles and its elimination are studied. Organic phosphorus extractants such as HDEHP,HEHEHP are used as extractants.Several solvents are tested, and the results indicate that it is feasible to use hydrogcnated kerosene instead of xylene (or toluene) as solvent in the determination of α-particles.The method is accurate and less labor-consuming. Its detective efficiency is rather high.