微波定位氚标记——Ⅰ.7-~3H四环素的制备

APPLICATION OF THE MICROWAVE DISCHARGE METHOD FOR THE SPECIFIC ~3H-LABELING——I. PREPARATION OF 7-~3H TETRACYCLINE

摘要: <正> 一、引言四环素被发现卅年来,曾作为有效的广谱抗菌素在临床上获得了较为广泛的应用。之后,确认四环素荧光法对于筛选恶性肿瘤为一种比较有效的工具。当发现四环素对癌细胞有强烈的亲和性之后,曾提出将氘标记四环素用作治疗对人类有极大危害的恶性肿瘤的放化药物。我们最近的临床实践表明,7一~3H四环素对于诊断胃癌而言,不仅方法

Abstract: In this paper the preparation of 7- 3H tetracycline is accomplished with microwave discharge method. The results show that this labeling method is rapid and simple, resulting in high specific activity and high radiochemical purity.