Abstract: Applications of radiopharmaceuticals in the nervous system, cardiovascular, tumor, hypoxia, and gene imaging are described, and the new research aspects may be provided in the coming years：computer-aided design of radiopharmaceuticals；screening the lead compound by combination chemistry and phage display；chemical modification of existing radio-
pharmaceuticals；developing the PET tracer, the new radiolabeling technique；chemistry of Tc and Re；development of the new radionuclide for diagnosis or therapy, etc.