Abstract: LABELING IgG WITH 211At VIA DTPA ANHYDRIDELiu Ning Jin Jiannan Mo Shangwu Chen Hengliu Yu Yanping(Institute of Nuclear Science and Technology,Sichuan University,Chengdu 610064)ABSTRACTA method for labeling human IgG with 211At via DTPA anhydride is described.DTPAIgG is prepared and 211At is conjugated to human IgG by adding Na　211At to DTPAIgG and reaction for 30min at room temperature.The astatinated IgG is isolated by a Sephadex G50 column and identified by size exclusion HPLC.The labeling procedure is executed in 1.5h and at least 60% of the added 211At are found in the product.The stability of 211At DTPAIgG in vitro and vivo is evaluated.Keywords 211At Labeling method DTPA IgG Stability Biodistribution