无载体~(18)F的制备及快速标记

    PREPARATION OF CARRIER-FREE ~(18)F-FLUORIDE USING A SERIES OF LITHIUM CROWN COMPLEXES AS A TARGET FOR RAPID LABELLING OF HALOGENATED HYDROCARBONS

    • 摘要: 研究了以苯并-12-冠-4、15-冠-5、18-冠-6、二苯并-24-冠-8的锂络合物为靶子,在反应堆内照射,通过~6Li(n,t)~4He,~(16)O(t,n)~(18)F二次核反应制备无载体~(18)F,并以靶子物冠醚为溶剂直接进行了~(18)F的快速标记。由于~(18)F~-的“裸露”离子效应,加速了~(18)F~-与CH_2Br(CH_2)_(14)CH_3化合物中Br~-之间的交换,标记率>90%,产额80±5%。本方法把~(18)F的制备、分离和标记统一起来,操作时间较短,适合于短半衰期~(18)F快速标记的需要。

       

      Abstract: A new method is described for the preparation of reactor-produced carrier-free 18F using Li2CO3 complexed with benzo-12-crown-4, 15-crown-5, 18-crown-6, dibenzo-24-crown-8 as a target for subsequent synthesis of labelled organic compounds. The relative yields of these targets are approximately 38% for benzo-12-crown-4, 53% for 15-crown-5, 55% for 18-crown-6 and 37% for dibenzo-24-crown-8 compared with the pure Li2CO3 target for the same quantity of lithium. After irradiation, this target was used as a solvent for synthesis of halogenated compounds. The labelling yields of CH2 18F (CH2)14CH3 typically reach 80±5% within 40 min at 60℃. The combination of preparation and labelling in one step makes this method very attractive for labelling of halogenated hydrocarbons with carrier-free 18F.

       

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