细胞凋亡显像剂［<sup>18</sup>F］FEDPA的合成和标记

细胞凋亡显像剂［¹⁸F］FEDPA的合成和标记

摘要: 为制备新型细胞凋亡显像剂［¹⁸F］FEDPA，合成了前体(2-2-［2-(3,5-二-N,N-二(2-甲基吡啶)氨甲基-苯氧基)乙氧基］-乙氧基乙基)-胺，总收率5%（以化合物4计）。后经过¹⁸F标记合成［¹⁸F］FEDPA，标记率(8.9±0.3)%(经校正，n=2)，HPLC检测其放射化学纯度为77%。

Abstract: Synthesis and fluoro-radiolabelling of apoptosis imaging agent ［¹⁸F］FEDPA were reported. The labeling precursor 2-2-［2-(3,5-bis(2,2’-dipicolyaminomeyhyl)-phenoxy)ethoxy］-ethoxyethyl amine was prepared with the total yield of 5%(based on compound 4). ¹⁸F-labeling of the precursor gave ［¹⁸F］FEDPA. The radiochemical yield is (8.9±0.3)% (n=2, decay corrected) and radiochemical purity is 77% determined by HPLC.