Abstract: The uranium(Ⅵ) in uranium waste rock leachate could directly threaten human health and surrounding environment after its entering into soil through food chain. On the basis of present the domestic and foreign researches, this paper reviewes the source and classification of soil colloids, and generalizes the interaction between uranium(Ⅵ) and soil colloids. The blocking effects of the structure of soil colloids, the form of uranium ions, Eh and pH value of soil, ionic strength and organic matters on uranium(Ⅵ) adsorption process are discussed. As well as the application progress of colloid are presented. Moreover, several suggestions are proposed for how to present the breakthrough in long-term affecting the environmental of uranium(Ⅵ) which is in uranium waste rock leachate.