Abstract: The effect of various factors on UO₂ microspheres with titanium-doped can be obtained by the preparing experiment. The addition of surfactant Span80 can contribute to lessen the adhesion between gel balls, though it can’t be eliminated completely. When the added amount of Span80 is more than 0.15%, the roundness sphericity of gel balls is reduced evidently. Extending gelatinization time can not only resolve the problem of extrusion and distortion but also the adhesion between gel balls. The smoothness of UO₂ microspheres with doped titanium is increasing with the decreasing of sintering temperatures. The doped titanium is helpful for the sintering of UO₂ microspheres. With concentrated HNO₃(w=68%) and high-purity H₂O (V(HNO₃)∶V(H₂O)=2∶1) as erodent, the grain boundary of the microsphere shows soon.