Abstract:
123I with radioactivity of 11.1 TBq/(A•h) and nuclear purity of more than 98.6% was prepared in the CS-30 cyclotron of Sichuan University via
121Sb（α,2n）
123I nuclear reaction by α-energy of 26.5 MeV and using Sb target of 62.2-64.3 mg/cm
2. Furthermore, V
HCDR
1-V
HFR
2-V
LCDR
3, a new fusion peptide was labeled with
123I, and
in vitro and
in vivo of the labeled peptide was evaluated. The results show that the labeling yield of
123I V
HCDR
1-V
HFR
2-V
LCDR
3 is more than 90%. The deiodination of
123I labeled V
HCDR
1-V
HFR
2-V
LCDR
3 in vivo is minimal, and
123I V
HCDR
1-V
HFR
2-V
LCDR
3 has a high stability
in vitro.
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