SYNTHESIS OF 3-~3H -4β,15-DIACETOXY 8a-(3- METHYLBUTYRYLOXY)-3a-HYDROXY-12, 13-EPO-XYTRICHOTHEC-9-ENE

3-3H-4β, 15-diacetoxy, 8α- (3-methylburyloxy) -3α-hydroxy-12, 13-epoxy trichothec-9-ene is synthetized by oxidizing the C-3-hydroxy to ketone . It is reduced with NaB3H4 to a mixture of epimers which are separable by high thin-layer chromatography. The specific activity is 629 GBq/mmol and radio-themical parity is over 98%. Specific activity of this tritium labeled T-2-toxin is higher than that by Wallace.