Apparent Partition Coefficient in Octanol-Water and Binding Percentage to BSA of ~(153)Sm~(113,117)Sn~m Complexes

Apparent partition coefficient in octanol-water and binding percentage to BSA of ~(153)Sm-NTMP, ~(153)Sm-HEDTMP, ~(153)Sm-DCTMP, ~(153)Sm-EDTMP, ~(153)Sm-DTPMP, ~(113,117) Sn~m-EDTMP, ~(113,117) Sn~m-HEDTMP, ~(113,117) Sn~m-DTPMP are measured. The results show that there is a linear relationship between the relative magnitude of the apparent partition coefficient in octanol-watetr and the relative magnitude of the binding percentage to BSA of these ~(153)Sm(~(113,117)Sn~m) complexes. This linear relationship provides a new method for determination of the apparent partition coefficient in octanol-water of ~(153)Sm(~(113,117)Sn~m) complexes of this kind. This linear relationship also implicates that hydrophobic force plays an important role in the binding of ~(153)Sm(~(113,117)Sn~m)complexes to BSA.